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pentobarbital will reduce the level or effect of phenytoin by impacting hepatic enzyme CYP2C9/ten metabolism. Use Warning/Keep an eye on.Contraindicated (1)pentobarbital will reduce the extent or effect of cariprazine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is chargeable for the formation and elimination